Obstetrical and neonatal outcomes after single and double gamete donation

Main Article Content

Michelle Saltoft Skovrup
Maria Borgstrøm
Marie Louise Grøndahl
Ursula Bentin-Ley
Kaare Rygaard
Jimmi Elers
Pernille Fog Svendsen


Introduction: An increasing number of women and couples need oocyte donation to help achieve pregnancy. Several studies have found a correlation between the use of oocyte donation and adverse obstetrical outcomes such as gestational hypertension and preeclampsia. A possible additive risk in using double donation (oocyte and sperm donation) compared to the use solely of oocyte donation has been suggested but only sparsely investigated. The aim of this study is to investigate the differences in obstetric and neonatal outcomes after double donation compared to oocyte donation.
Methods: This is a retrospective cohort study of 197 women, who achieved pregnancy after oocyte donation between 2015 and 2022. The primary outcomes investigated were gestational hypertension and preeclampsia. Secondary outcomes were early pregnancy loss, HELLP (Hemolysis, Elevated Liver enzymes, and Low Platelets) syndrome, fetal growth restriction, and gestational diabetes mellitus.
Results: No significant differences between the use of oocyte and double donation were observed, when looking at the risk of developing gestational hypertension (AOR = 1.02, 95%CI = [0.33;3.15], P = 0.97) or preeclampsia (AOR = 2.4, 95%CI = [0.68;8.41], P = 0.17). We observed no significant differences between the two groups regarding any of the secondary outcomes.
Conclusion: This study did not find an increased risk of obstetrical or neonatal complications such as preeclampsia, gestational diabetes mellitus, or fetal growth restriction after double donation compared to oocyte donation.

Article Details

How to Cite
Skovrup, M., Borgstrøm, M., Grøndahl, M. L., Bentin-Ley, U., Rygaard, K., Elers, J., & Fog Svendsen, P. (2023). Obstetrical and neonatal outcomes after single and double gamete donation. Danish Journal of Obstetrics and Gynaecology, 2(1), 4–14. https://doi.org/10.56182/djog.v2i1.27
Author Biographies

Maria Borgstrøm, Fertilitetsklinikken - Herlev Hospital


Marie Louise Grøndahl, Fertilitetsklinikken - Herlev Hospital

DM.Sci., PhD

Ursula Bentin-Ley, Dansk Fertilitetsklinik


Kaare Rygaard, Fertilitetsklinikken Trianglen

MD, D.M.Sci

Jimmi Elers, TFP Stork Fertility


Pernille Fog Svendsen, Fertilitetsklinikken - Herlev Hospital

MD, D.M.Sci


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