Placental Mesenchymal Dysplasia – a case report

Main Article Content

Adna Mohamud
https://orcid.org/0000-0002-0239-1450
Tina D. Hjortshøj
Christian B. Brøchner
https://orcid.org/0000-0001-6838-6729
Louise S. Hornstrup

Abstract

Placental mesenchymal dysplasia (PMD) is a very rare vascular placenta anomaly, characterized by an enlarged placenta with grape-like vesicles. Initially, the disease can be mistaken for a molar pregnancy on ultrasound, but the condition is not a trophoblastic disorder, and presents with unique diagnostic and clinical features. Genetically, there is an association with androgenic/biparental mosaicism which can be confined to the placenta but also can be present in the fetus, and there is an increased risk of imprinting disorders such as Beckwith-Wiedemann syndrome. Obstetrically, PMD is associated with fetal growth restriction, preeclampsia, preterm delivery, and increased risk of intrauterine fetal demise. Thus, PMD is often associated with severe maternal and/or fetal complications, and this case illustrates the challenge in the diagnosis and prenatal counseling.

Article Details

How to Cite
Placental Mesenchymal Dysplasia – a case report. (2025). Danish Journal of Obstetrics and Gynaecology, 3(1), 29-33. https://doi.org/10.56182/c4h8g318
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Articles
Author Biographies

Tina D. Hjortshøj, Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Christian B. Brøchner, Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Louise S. Hornstrup, Department of Gynecology and Obstetrics, Copenhagen University Hospital Herlev-Gentofte, Herlev, Denmark

Department of Gynecology and Obstetrics, Copenhagen University Hospital Herlev-Gentofte, Herlev, Denmark

How to Cite

Placental Mesenchymal Dysplasia – a case report. (2025). Danish Journal of Obstetrics and Gynaecology, 3(1), 29-33. https://doi.org/10.56182/c4h8g318

References

1. Bernabeu R, Villar I, Goy E, Martinez-Payo C. Intrauterine Growth Restriction Associated with Hematologic Abnormalities: Probable Manifestations of Placental Mesenchymal Dysplasia. American Journal of Perinatology Reports. 2015 Jun 9;05(02):e085–8. DOI: https://doi.org/10.1055/s-0034-1394152

2. Parveen Z, Tongson-Ignacio JE, Fraser CR, Killeen JL, Thompson KS. Placental Mesenchymal Dysplasia. Archives of Pathology & Laboratory Medicine. 2007 Jan 1;131(1):131–7. DOI: https://doi.org/10.5858/2007-131-131-PMD

3. Khong TY, Mooney EE, Ariel I, Balmus NCM, Boyd TK, Brundler MA, et al. Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement. Archives of Pathology & Laboratory Medicine. 2016 Jul;140(7):698–713. DOI: https://doi.org/10.5858/arpa.2015-0225-CC

4. Hidenobu Soejima, Hara S, Takayoshi Ohba, Higashimoto K. Placental Mesenchymal Dysplasia and Beckwith–Wiedemann Syndrome. Cancers. 2022 Nov 12;14(22):5563–3. DOI: https://doi.org/10.3390/cancers14225563

5. Wang SJ, Lin LL, Chen WC. Placental mesenchymal dysplasia complicated with sudden fetal demise and amniotic fluid embolism: a case report. BMC Pregnancy and Childbirth [Internet]. 2022 Dec 9;22:927. DOI: https://doi.org/10.1186/s12884-022-05261-2

6. Chisato Kodera, Aoki S, Takashi Ohba, Higashimoto K, Mikami Y, Fukunaga M, et al. Clinical manifestations of placental mesenchymal dysplasia in Japan: A multicenter case series. Journal of Obstetrics and Gynaecology Research [Internet]. 2021 Jan 18 [cited 2024 Aug 24];47(3):1118–25. DOI: https://doi.org/10.1111/jog.14647

7. Tang P, Jin X, Li J, Zhang L, Li Y, Xu S. Misdiagnosis of placental mesenchymal dysplasia as pregnancy with hydatidiform mole: A case report and literature review. Medicine [Internet]. 2023 Apr 14;102(15):e33438. DOI: https://doi.org/10.1097/MD.0000000000033438